ABSTRACT
Background: Epithelial ovarian carcinoma is worldwide the sixth most common female cancer. This malignancy carries the highest mortality among all gynecological cancers. Aim and objectives: To perform and interpret p53 immunostaining on the diagnosed serous and mucinous malignant surface epithelial ovarian tumors and to correlate expression of p53 with histological type of malignancy. Materials and methods: 2 year prospective study was done i.e. from October 2011 to September 2013 on “p53 interpretation on surface epithelial ovarian tumors” in MGM Hospital, Warangal. All the ovarian surface epithelial tumor specimens, received in the pathology department during this period were considered. Results: A total of 120 cases were studied, out of which benign tumors were the most common (64.2%), followed by malignancy (25.8 %) and 12 cases (10%) of borderline malignancy. Most of the benign tumors were unilateral, the cases which showed bilateral involvement were mostly malignant. The maximum number of cases in the present study was seen in the age group of 31-60 years. The youngest patient was 16 years old and the oldest was 68 years old. Serous cyst adenoma was the most common neoplasm found and accounted for 53 cases (44.2%) , followed by mucinous cystadenoma, which accounted for 21 cases (17.5%). 9 cases of serous cystadenofibroma (7.5%), 3 borderline serous tumors (2.5%) and 11 serous cystadenocarcinoma (9.1%) were found in the present study. Out of the 44 mucinous tumors, 21 were benign (17.5%), 3 were of borderline malignancy (2.5%) and 20 were malignant (16.7%). One case of mucinous cystadenocarcinoma was found to be associated with T. T. Sreeja, S. Chandrasekhar, S. Lokesh Rao Magar, K. Durga. 2 years study on p53 expression on serous and mucinous tumors of ovary. IAIM, 2016; 3(7): 150-158. Page 151 adenocarcinoma of ascending colon. One case of benign Brenner tumour was also found in the present study. Conclusion: The rate of p53 abnormalities varies with histologic type, grade and stage of the tumor. P53 expression was more in malignant serous tumors as compared to the malignant mucinous tumors.
ABSTRACT
Aims and Objectives (1) To perform and interpret p53 immunostaining on the diagnosed malignant surface epithelial ovarian tumours. (2) To correlate expression of p53 with histological type of malignancy. Materials and Methods A 2-year prospective study was done i.e., from October 2011 to September 2013 on ‘A study on expression of p53 in surface epithelial ovarian tumours’ in MGM Hospital, Warangal. All the ovarian surface epithelial tumour specimens, received in the pathology department during this period were considered. Results A total of 121 cases were studied, out of which benign tumours were the most common (64.4%), followed by malignancy (25.6%) and 12 cases(10%) of borderline malignancy. Most of the benign tumours were unilateral; the cases that showed bilateral involvement were mostly malignant. The maximum number of cases in the present study was seen in the age group of 31–60 year. The youngest patient was 16 year old and the oldest was 68 year old. Serous cyst adenoma was the most common neoplasm found and accounted for 53 cases (43.8%), followed by mucinous cystadenoma, which accounted for 21 cases (17.3%). Nine cases of serous cystadenofibroma (7.43%), 3 borderline serous tumours (2.47%) and 11 serous cystadenocarcinoma (9%) were found in the present study. Out of the 44 mucinous tumours, 21 were benign (17.3%), 3 were of borderline malignancy (2.47%) and 20 were malignant (16.5%). One case of mucinous cystadenocarcinoma was found to be associated with adenocarcinoma of ascending colon. One case of benign Brenner tumour was also found in the present study. The rate of p53 abnormalities varies with histological type, grade and stage of the tumour. P53 expression was more in malignant serous tumours as compared to the malignant mucinous tumours.
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Limbal squamous cell carcinoma is uncommon worldwide. Its early stages of presentation may look like the commoner limbal mass, pterygium or actinic keratosis. We report a case of invasive squamous cell carcinoma of limbusin a 45-year female patient. A high index of suspicion is required to prevent delay in the diagnosis of an invasive condition that can destroy the eye completely[1]. A rare case of squamous cell carcinoma of the conjunctiva is presented here. This highlights the significance of aggressive management of such cases surgically and the use of adjuants per operatively to prevent recurrence.
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ACA territory is an uncommon site for occlusive vascular strokes. Small degree of asymmetry of anterior arteries is present in 80% of patients. Common variants of anterior cerebral arteries include aplasia or hypoplasia of A1 segment. Hypoplasia is found in 10% and aplasia in 1-2% of postmortem examinations. Of all ischemic strokes ACA territory strokes constitutes only 0.6 to 3%. Bilateral ischemic stroke in unpaired ACA is rare entity. We report a case of unpaired ACA due to hypoplasia of right ACA, presenting as stuttering hemiplegia with bilateral focal neurological deficit.
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L-Lactate dehydrogenase is an oxidoreductase that catalyzes the reversible inter-conversion of pyruvate to L-lactate under anaerobic conditions. Levels of Lactate dehydrogenase are known to be elevated in the blood stream following severe tissue injuries and necrosis. Since cancer is a proliferating and invasive disease known to cause severe tissue damage and tumour cells respire anaerobically, the present study was planned to evaluate variations in the levels of serum LDH in breast cancer as compared to normal. LDH levels were estimated in 130 patients with a confirmed diagnosis of breast cancer and also in 110 healthy age matched randomly selected controls. Appropriate statistical tests were used to assess variations in LDH levels with respect to the presence of disease, age at onset and menopausal status of the proband, stage of the disease and mode of anti-cancer therapy followed Lactate dehydrogenase levels were found to be significantly elevated in breast cancer (302.45 + 7.67) as compared to control (173.77 + 3.4). Significant elevations in LDH levels were also observed with increasing age at onset, onset of menopause, advance stage of cancer and due to the anti-cancer treatment followed. These results suggest an immense potential for LDH as a prognostic marker for breast cancer.
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The influence of parental literacy and socio-economic status (SES) on infant mortality rate (IMR) was studied. This report is only a part of much larger community-based prospective study conducted to determine the factors influencing infant mortality in Dakshina Kannada district of Karnataka, by the Department of Community Medicine, Kasturba Medical College, Manipal, with the financial assistance form IDRC, Canada. A total of 12,857 livebirths during the period of October 1, 1991, to September 30, 1992, where registered and followed up for one year. There were 391 infant deaths which gives an IMR of 30.4 per 1,000 livebirths. Univariate analysis and subsequent stepwise multiple logistic regression analysis revealed that, literacy and SES have a very significant role in reducing IMR.
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Cause of Death , Developing Countries , Educational Status , Female , Humans , India/epidemiology , Infant , Infant Mortality , Infant, Newborn , Male , Prospective Studies , Socioeconomic FactorsABSTRACT
A total of 4,554 sputum specimens of 3,943 patients were examined with a view to isolate atypical mycobacteria. Of these 604 (13.3%) specimens were culture positive for AFB, out of which 48 cultures (7.9%) from 47 patients were identified as atypical mycobacteria. Two patients were considered as probable cases of atypical mycobacterial disease while in the remaining 45 patients, atypical mycobacteria appeared to colonize the lungs without producing any disease.